The Protective Effect of Lycopene on Toxicity of Aflatoxin B1 in Rats

Seval Yilmaz1 and Emre Kaya2

1,21,2Department of Biochemistry, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey Authors Email: sevalyilmaz@firat.edu.tr1 and emrekaya@firat.edu.tr2 Authors ORCIDs: 0000-0002-2040-92471 and 0000-0002-7445-30912

ABSTRACT It is aimed to determine the oxidative damage which may be caused by aflatoxin (AF) B1 and the inhibitory effect of lycopene against this damage. Groups were formed as; control group, lycopene-treated group, low dose AFB1-treated group and high dose AFB1-treated group,low dose AFB1+lycopene-treated group and high dose AFB1+lycopene-treated group. Malondialdehyde, glutathione levels and antioxidant enzyme activities were measured in blood samples. It was observed a significant increase in malondialdehyde level, decrease in glutathione level and antioxidant enzyme activities in low and high dose AFB1-treated groups when compared with control group. It was determined a significant decrease in malondialdehyde level and an increase in glutathione level, antioxidant enzyme activities in low and high dose AFB1+lycopene-treated group when compared with low and high dose AFB1 group. In conclusion, it has been shown that lycopene which has antioxidant properties can be prevented from AFB1-induced toxicity.

Key words: Aflatoxin, antioxidant enzyme, glutathione, lycopene, malondialdehyde

Cite this article: Yilmaz, S., & Kaya, E. (2019). The Protective Effect of Lycopene on Toxicity of Aflatoxin B1 in Rats. European International Journal of Science and Technology, 8(5), 1-10.